PNH (Paroxysmal Nocturnal Hemoglobinuria)
Paroxysmal nocturnal hemoglobinuria (PNH) is an ongoing, progressive disease. It destroys an important part of your blood—the red blood cells — and can be life-threatening.
- PNH is an acquired disease, which means it develops in some people over time.
- In PNH, a change occurs in the stem cells in the body, including in the bone marrow, where red blood cells are produced.
- The stem cell change causes the lifelong production of “bad” cells—cells that are missing important protective proteins.
Without these proteins, your body’s natural defense system destroys PNH red blood cells (a process called hemolysis). Hemolysis happens constantly and at high rates in PNH, which could put you at risk for serious health problems. Hemolysis is the main cause of the major health problems in PNH, including the most severe.
APLASTIC ANEMIA & MDS INTERNATIONAL FOUNDATION
A nonprofit resource for assistance, advocacy, and support for patients living with AA, MDS, and PNH.
NATIONAL INSTITUTES OF HEALTH
Part of the US Department of Health and Human Services and a trusted source of research.
NATIONAL ORGANIZATION FOR RARE DISORDERS (NORD)
Dedicated to helping people with rare disorders like PNH.
Alexion-sponsored disease website for patients and healthcare professionals.