Meet the Team

Meet your OneSource^™ Team.

At OneSource^™, our team of specialists is trained in rare diseases. They can provide information about your or your loved one's condition, Alexion treatment, insurance coverage, and more.

A Case Manager and a Patient Education Manager will help support you along your or your loved one's journey with KOSELUGO^® (selumetinib).

Watch these videos to meet members of the OneSource^™ team.

MEET A CASE MANAGER

Your dedicated Case Manager can:

Answer questions about Koselugo and NF1 plexiforms
Provide support during treatment
Help avoid interruptions in treatment during insurance changes, travel, or other life events
Help you and your child get involved with the rare disease community through events and meetings

MEET A Patient Education manager (PEM)

A PEM can:

Host local patient educational initiatives
Conduct treatment education sessions for patients
Meet with you or your loved one, in person or by phone, to provide education

Find a PEM Near You

MEET A CASE MANAGER

Your dedicated Case Manager can:

Answer questions about Koselugo and NF1 plexiforms
Provide support during treatment
Help avoid interruptions in treatment during insurance changes, travel, or other life events
Help you and your child get involved with the rare disease community through events and meetings

MEET A Patient Education manager (PEM)

A PEM can:

Host local patient educational initiatives
Conduct treatment education sessions for patients
Meet with you or your loved one, in person or by phone, to provide education

Find a PEM Near You

INDICATION & IMPORTANT
SAFETY INFORMATION for
KOSELUGO^® (selumetinib) 10mg & 25mg capsules and 5mg & 7.5mg oral granules

IMPORTANT SAFETY INFORMATION

What are the possible side effects of Koselugo?

Koselugo may cause serious side effects, including:

Heart problems. Koselugo can lower the amount of blood pumped by your heart, which can be severe. Your healthcare provider will do tests before and during treatment to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms: persistent coughing or wheezing, shortness of breath, swelling of your ankles and feet, tiredness, increased heart rate.
Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment. Tell your healthcare provider right away if you get new or worsening vision changes, including: blurred vision, loss of vision, dark spots in your vision (floaters), other changes to your vision..
Stomach, intestine, and mouth (gastrointestinal) problems. Koselugo can cause diarrhea, vomiting, nausea, and mouth sores. Diarrhea can be severe with Koselugo. Tell your healthcare provider right away the first time that you get diarrhea during treatment. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

INDICATION

What is Koselugo?

Koselugo is a prescription medicine that is used to treat adults and children 1 year of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 1 year of age.

Please see Patient Information in the full Prescribing Information for Koselugo (selumetinib).

Skin problems. Koselugo can cause severe skin rashes. Tell your healthcare provider if you get any of the following signs of skin problems: rash that covers a large area of your body, flat skin rash, raised bumps on your skin, skin bumps that look like acne, blisters, peeling skin, itchy rash, hair thinning or hair loss (alopecia).
Increased level of an enzyme called creatine phosphokinase (CPK) in your blood and muscle problems. Koselugo can cause severe muscle problems. Treatment with Koselugo may increase the level of an enzyme in your blood called creatine phosphokinase (CPK), which may be a sign of muscle damage. Increased level of CPK in the blood is common during treatment and can also be severe. Your healthcare provider should do a blood test to check your blood levels of CPK before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms: muscle aches or pain; muscle spasms and weakness; dark, reddish urine.

Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects.

Before taking Koselugo, tell your healthcare provider about all your medical conditions, including if you:

Have heart problems.
Have eye problems.
Have liver problems.
Females who are able to become pregnant:
- Your healthcare provider should check to see if you are pregnant before you begin treatment.
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.
Males with female partners who are able to become pregnant:
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
Are breastfeeding or plan to breastfeed. It is not known if Koselugo passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, or herbal supplements. Certain medicines may affect the way Koselugo works. Especially tell your healthcare provider if you are taking a supplement containing vitamin E, aspirin, blood thinners, or other medicines to treat blood clots. Koselugo capsules contain vitamin E, which may increase risk of bleeding.

What should I avoid while taking Koselugo?

Avoid St John’s wort, grapefruit or grapefruit juice, and Seville oranges during treatment.

Most common side effects in children include: vomiting, diarrhea, increased level of an enzyme called creatine phosphokinase (CPK) in your blood, dry skin, redness around the fingernails, nausea, skin bumps that look like acne, fever.

Most common side effects in adults include: rash, diarrhea, skin bumps that look like acne.

These are not all the possible side effects of Koselugo. Call your healthcare provider for medical advice about side effects. You may report side effects to AstraZeneca at 1-800-236-9933 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information and Instructions for Use in the full Prescribing Information for Koselugo (selumetinib).

IMPORTANT SAFETY INFORMATION

What are the possible side effects of Koselugo?

Koselugo may cause serious side effects, including:

Heart problems. Koselugo can lower the amount of blood pumped by your heart, which can be severe. Your healthcare provider will do tests before and during treatment to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms: persistent coughing or wheezing, shortness of breath, swelling of your ankles and feet, tiredness, increased heart rate.
Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment. Tell your healthcare provider right away if you get new or worsening vision changes, including: blurred vision, loss of vision, dark spots in your vision (floaters), other changes to your vision..
Stomach, intestine, and mouth (gastrointestinal) problems. Koselugo can cause diarrhea, vomiting, nausea, and mouth sores. Diarrhea can be severe with Koselugo. Tell your healthcare provider right away the first time that you get diarrhea during treatment. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

Skin problems. Koselugo can cause severe skin rashes. Tell your healthcare provider if you get any of the following signs of skin problems: rash that covers a large area of your body, flat skin rash, raised bumps on your skin, skin bumps that look like acne, blisters, peeling skin, itchy rash, hair thinning or hair loss (alopecia).
Increased level of an enzyme called creatine phosphokinase (CPK) in your blood and muscle problems. Koselugo can cause severe muscle problems. Treatment with Koselugo may increase the level of an enzyme in your blood called creatine phosphokinase (CPK), which may be a sign of muscle damage. Increased level of CPK in the blood is common during treatment and can also be severe. Your healthcare provider should do a blood test to check your blood levels of CPK before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms: muscle aches or pain; muscle spasms and weakness; dark, reddish urine.

Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects.

Before taking Koselugo, tell your healthcare provider about all your medical conditions, including if you:

Have heart problems.
Have eye problems.
Have liver problems.
Females who are able to become pregnant:
- Your healthcare provider should check to see if you are pregnant before you begin treatment.
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.
Males with female partners who are able to become pregnant:
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
Are breastfeeding or plan to breastfeed. It is not known if Koselugo passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, or herbal supplements. Certain medicines may affect the way Koselugo works. Especially tell your healthcare provider if you are taking a supplement containing vitamin E, aspirin, blood thinners, or other medicines to treat blood clots. Koselugo capsules contain vitamin E, which may increase risk of bleeding.

What should I avoid while taking Koselugo?

Avoid St John’s wort, grapefruit or grapefruit juice, and Seville oranges during treatment.

Most common side effects in children include: vomiting, diarrhea, increased level of an enzyme called creatine phosphokinase (CPK) in your blood, dry skin, redness around the fingernails, nausea, skin bumps that look like acne, fever.

Most common side effects in adults include: rash, diarrhea, skin bumps that look like acne.

These are not all the possible side effects of Koselugo. Call your healthcare provider for medical advice about side effects. You may report side effects to AstraZeneca at 1-800-236-9933 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information and Instructions for Use in the full Prescribing Information for Koselugo (selumetinib).

INDICATION

What is Koselugo?

Koselugo is a prescription medicine that is used to treat adults and children 1 year of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 1 year of age.

Please see Patient Information in the full Prescribing Information for Koselugo (selumetinib).

INDICATION

Expand

What is Koselugo?

Koselugo is a prescription medicine that is used to treat adults and children 1 year of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 1 year of age.

Please see Patient Information in the full Prescribing Information for Koselugo (selumetinib).

INDICATION & IMPORTANT
SAFETY INFORMATION for
KOSELUGO^® (selumetinib) 10mg & 25mg capsules and 5mg & 7.5mg oral granules

Expand

IMPORTANT SAFETY INFORMATION

What are the possible side effects of Koselugo?

Koselugo may cause serious side effects, including:

Heart problems. Koselugo can lower the amount of blood pumped by your heart, which can be severe. Your healthcare provider will do tests before and during treatment to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms: persistent coughing or wheezing, shortness of breath, swelling of your ankles and feet, tiredness, increased heart rate.
Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment. Tell your healthcare provider right away if you get new or worsening vision changes, including: blurred vision, loss of vision, dark spots in your vision (floaters), other changes to your vision..
Stomach, intestine, and mouth (gastrointestinal) problems. Koselugo can cause diarrhea, vomiting, nausea, and mouth sores. Diarrhea can be severe with Koselugo. Tell your healthcare provider right away the first time that you get diarrhea during treatment. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

Skin problems. Koselugo can cause severe skin rashes. Tell your healthcare provider if you get any of the following signs of skin problems: rash that covers a large area of your body, flat skin rash, raised bumps on your skin, skin bumps that look like acne, blisters, peeling skin, itchy rash, hair thinning or hair loss (alopecia).
Increased level of an enzyme called creatine phosphokinase (CPK) in your blood and muscle problems. Koselugo can cause severe muscle problems. Treatment with Koselugo may increase the level of an enzyme in your blood called creatine phosphokinase (CPK), which may be a sign of muscle damage. Increased level of CPK in the blood is common during treatment and can also be severe. Your healthcare provider should do a blood test to check your blood levels of CPK before you start taking Koselugo and during treatment. Tell your healthcare provider right away if you get any of the following signs or symptoms: muscle aches or pain; muscle spasms and weakness; dark, reddish urine.

Your healthcare provider may change your dose, temporarily stop, or permanently ask you to stop taking Koselugo if you have any of these side effects.

Before taking Koselugo, tell your healthcare provider about all your medical conditions, including if you:

Have heart problems.
Have eye problems.
Have liver problems.
Females who are able to become pregnant:
- Your healthcare provider should check to see if you are pregnant before you begin treatment.
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.
Males with female partners who are able to become pregnant:
- You should use effective birth control (contraception) during treatment and for 1 week after your last dose.
Are breastfeeding or plan to breastfeed. It is not known if Koselugo passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, or herbal supplements. Certain medicines may affect the way Koselugo works. Especially tell your healthcare provider if you are taking a supplement containing vitamin E, aspirin, blood thinners, or other medicines to treat blood clots. Koselugo capsules contain vitamin E, which may increase risk of bleeding.

What should I avoid while taking Koselugo?

Avoid St John’s wort, grapefruit or grapefruit juice, and Seville oranges during treatment.

Most common side effects in children include: vomiting, diarrhea, increased level of an enzyme called creatine phosphokinase (CPK) in your blood, dry skin, redness around the fingernails, nausea, skin bumps that look like acne, fever.

Most common side effects in adults include: rash, diarrhea, skin bumps that look like acne.

These are not all the possible side effects of Koselugo. Call your healthcare provider for medical advice about side effects. You may report side effects to AstraZeneca at 1-800-236-9933 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Patient Information and Instructions for Use in the full Prescribing Information for Koselugo (selumetinib).

INDICATION & IMPORTANT
SAFETY INFORMATION for
KOSELUGO^® (selumetinib) 10mg & 25mg capsules and 5mg & 7.5mg oral granules

Expand

IMPORTANT SAFETY INFORMATION

What are the possible side effects of Koselugo?

Koselugo may cause serious side effects, including:

Heart problems. Koselugo can lower the amount of blood pumped by your heart, which can be severe. Your healthcare provider will do tests before and during treatment to check how well your heart is working. Tell your healthcare provider right away if you get any of the following signs or symptoms: persistent coughing or wheezing, shortness of breath, swelling of your ankles and feet, tiredness, increased heart rate.
Eye problems. Koselugo can cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment. Tell your healthcare provider right away if you get new or worsening vision changes, including: blurred vision, loss of vision, dark spots in your vision (floaters), other changes to your vision..
Stomach, intestine, and mouth (gastrointestinal) problems. Koselugo can cause diarrhea, vomiting, nausea, and mouth sores. Diarrhea can be severe with Koselugo. Tell your healthcare provider right away the first time that you get diarrhea during treatment. Your healthcare provider may give you medicine to help control your diarrhea and may tell you to drink more fluids.

INDICATION

What is Koselugo?

Koselugo is a prescription medicine that is used to treat adults and children 1 year of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.

It is not known if Koselugo is safe and effective in children under 1 year of age.

Please see Patient Information in the full Prescribing Information for Koselugo (selumetinib).